Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 4'-Pyrrolidin-1-ylmethyl-biphenyl-4-carbaldehyde oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | 4'-Pyrrolidin-1-ylmethyl-biphenyl-4-carbaldehyde | HCID 9813938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4'-Pyrrolidin-1-ylmethyl-biphenyl-4-carbaldehyde oxime | HCID 73415523 | 33.7% |
반응 단계
A solution of Example 27 (33.7 mg), sodium carbonate (27.6 mg), and hydroxylamine hydrochloride (18 mg) in ethanol (5 mL) was set to reflux for 16 hours. Inorganic solid was filtered out and washed with DCM and acetone. Organic layer was concentrated under reduced pressure to give the titled compound (12 mg) without purification. 1H NMR (400 MHz, CDCI3)δ8.19 (s, 1 H), 7.82-7.69 (m, 8 H), 4.37 (d, J=6.3, 2 H), 3.35 (m, 2 H), 3.10-3.03 (m, 2 H), 2.06-1.94 (m, 2 H), 1.93-1.88 (m, 2 H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06638967B2 |
| 출처 데이터셋 | uspto-grants-2003_10 |
| ORD ID | ord-13ed004ddf744982968e36e7e5a8dc90 |
| 출처 메모 | uspto-grants-2003_10 |