Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 2736733 | — |
| 반응물 | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| 생성물 | N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide | HCID 10833686 | 73% |
반응 단계
N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide was prepared in the same manner as described in Example 10 from 5-amino-4-bromo-3-methylisoxazole and 2-(carbomethoxy)thiophene-3-sulfonyl chloride in 73% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 198-200° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06458805B2 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-ffe307328f4b41e4be0a670278fe7ef9 |
| 출처 메모 | uspto-grants-2002_10 |