Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → 2-Chloro-6-(3-fluoro-phenyl-amino)-purine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 3-Fluoroaniline | HCID 9742 | — |
| 반응물 | 2,6-Dichloropurine | HCID 5324412 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 2-Chloro-6-(3-fluoro-phenyl-amino)-purine | HCID 21988328 | — |
반응 단계
2 g (10.58 mmol) of 2,6-dichloro-purine and 5.9 g (52.9 mmol) of 3-fluoro-aniline (Fluka, Buchs, Switzerland) are stirred in 60 ml of n-butanol and 3 ml of DMF at 80° C. for 5 h. The cooled reaction mixture is treated with isopropanol and the crystal mass which has precipitated out is filtered off and dried. 2-Chloro-6-(3-fluoro-phenyl-amino)-purine is obtained; m.p.>250° C.; FAB-MS: (M+H)+=264; Rf=0.3 (CH2Cl2:methanol 9:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091346B1 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-b882d8a91c4f492da930efef14481420 |
| 출처 메모 | uspto-grants-2006_08 |