Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 18677662, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl 4-isocyanatopiperidine-1-carboxylate | HCID 2776273 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 18677662 | HCID 18677662 | 97.2% |
반응 단계
To 0.83 g (3.2 mmol) of (1-benzyloxycarbonylpiperidin-4-yl)isocyanate from Procedure 1, Step A in 10 mL was added 16 mL (32 mmol) of 2 M dimethylamine in THF. The reaction was stirred under nitrogen at rt for 24 h and then poured into water containing 20 mL of 2 N hydrochloric acid and was extracted twice with ethyl acetate. The organic layers were each washed with a portion of brine, dried over sodium sulfate, combined and concentrated to give 0.95 g of the crude title compound which can be used directly in subsequent reactions.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06472410B1 |
| 출처 데이터셋 | uspto-grants-2002_10 |
| ORD ID | ord-165a0af1764141a5913324af530f2a04 |
| 출처 메모 | uspto-grants-2002_10 |