反应详情

The title compound was prepared by hydrogenation of 3-(4-benzyloxy-phenyl)-l-cyclohexyl-prop-2-en-1-one (25.85 g, 84 mmol; prepared in Example C) as described in General Method 3 using 1.0 g of 5% Pd on BaSO4 in 600 mL of THF at room temperature. The crude product was flash chromatographed using CH2Cl2 :MeOH (99:1 to 98:2) to afford a gummy solid. 1H NMR (CDCl3) δ 1.1-1.9 (m, 10 H), 2.2-2.4 (m, 1 H), 2.68-2.74 (m, 2 H), 2.79-2.85 (m, 2 H), 5.04 (s, 2 H), 6.8-6.9 (d, 2 H), 7.1-7.2 (d, 2 H), 7.3-7.5 (m, 5H).

1. customchromatographed
2. customto afford a gummy solid