HRID1004944

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10910168

2-(TRIMETHYLSILYL)ETHYL CHLOROFORMATE

C6H13ClO2Si

结构：C[Si](C)(C)CCOCOc1cc(COC2CN(Cc3ccccc3)CCC2c2ccc(F)cc2)cc2ccccc12

HCID22127049

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCOCOc1cc(COC2CN(C(=O)OCC[Si](C)(C)C)CCC2c2ccc(F)cc2)cc2ccccc12

HCID86604391

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 1(d) by cleavage of the benzyl group by means of β-trimethylsilylethyl chloroformate from (3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine there was obtained β-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-yl-methoxy]-piperidine-1-carboxylate as a light yellow oil; MS: 626 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf02768e96784d4497390a7b91c6807b
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06051712
来源说明: uspto-grants-2000_04

反应 SMILES

Cl[C:2]([O:4][CH2:5][CH2:6][Si:7]([CH3:10])([CH3:9])[CH3:8])=[O:3].C([N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH:20]([O:31][CH2:32][C:33]2[CH:42]=[C:41]([O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:51])([CH3:50])[CH3:49])[C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[CH:34]=2)[CH2:19]1)C1C=CC=CC=1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH:21]2[CH2:22][CH2:23][N:18]([C:2]([O:4][CH2:5][CH2:6][Si:7]([CH3:10])([CH3:9])[CH3:8])=[O:3])[CH2:19][CH:20]2[O:31][CH2:32][C:33]2[CH:42]=[C:41]([O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:51])([CH3:50])[CH3:49])[C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[CH:34]=2)=[CH:25][CH:26]=1