反应详情

The compound 22 (345 mg, 1 mmol) was converted to the acetal with 1,1-di-n-propoxycycloheptane (2.14 g, 10 mmol) in the same manner as the example 20 to give the compound 27 (188 mg, 39.8%). PMR (CDCl3 -0.1% d5 -Py): δH0.87 (3 H, t, J 7.4 Hz, Pr) 1.24 (6 H, d, J 7 Hz, (CH3)2C), 3.00 (2 H, t, J 6 Hz, CH2 -Im), 3.05 (2 H, t, J 7 Hz, OCH2CH3), 3.09 (1 H, m, (CH3)2CH), 3.51 (3 H, s, NCH3), 3.71 (2 H, t, J 6 Hz, OCH2), 6.82 (2 H, d, J 1.6 Hz, arom-H), 7.11 (t-like, arom-H). IR(KBr)cm-1 : 3435, 3063, 1563, 1459, 1119, 1096, 1068, 1015. Elementary analysis (for C25H36N2O2Cl2S) Cacld.: C, 60.11% H, 7.26% N, 5.61% S, 6.42% Cl, 14.19% Found: C, 60.18% H, 7.30% N, 5.84% S, 6.55% Cl, 13.52%