反应详情

The compound 22 (345 mg, 1 mmol) was converted to the enol ether with 1-methoxycyclododecene (982 mg, 5 mmol) in the same manner as the example 41 to give the compound 49 (418 mg, 82%). Mp 96-102° C. PMR (CDCl3 -0.1% d5 -Py): δH1.24 (6 H, d, J 7 Hz, (CH3)2C), 3.11 (2 H, t, J 6.2 Hz, CH2 -Im), 3.10 (1 H, m, (CH3)2CH), 3.51 (3 H, s, NCH3), 3.96 (2 H, t, J 6.2 Hz, OCH2), 4.36 (1 H, t, J 7.8 Hz, =CH), 6.80 (2 H, d, J 1.6 Hz, arom-H), 7.10 (1 H, t-like, arom-H). IR(KBr)cm-1 : 3434, 3057, 1702, 1662, 1566, 1558, 1469, 1409, 1378, 1235, 1130. Elementary analysis (for C27H38N2Ocl2S) Calcd. : C, 63.64% H, 7.52% N, 5.50% S, 6.29% Cl, 13.91% Found: C, 64.48% H, 7.69% N, 5.10% S, 6.03% Cl, 12.85%