反应详情

A mixture of 2-[N-(3,4-dimethoxybenzyl)]aminothieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (0.06 g, 0.15 mmol) and TFA (2 mL) was refluxed for 2 h, cooled, concentrated in vacuo to half its original volume, diluted with CH2Cl2 (50 mL), washed with saturated sodium bicarbonate solution (3×25 mL) then brine (25 mL), dried (MgSO4), concentrated in vacuo and purified by chromatography [SiO2; heptane-EtOAc (3:1)] to give the title compound (40 mg, 100%) as a yellow solid.

1. temperaturewas refluxed for 2 h
2. temperaturecooled
3. concentrationconcentrated in vacuo to half its original volume
4. additiondiluted with CH2Cl2 (50 mL)
5. washwashed with saturated sodium bicarbonate solution (3×25 mL)
6. dry with materialbrine (25 mL), dried (MgSO4)
7. concentrationconcentrated in vacuo
8. custompurified by chromatography [SiO2; heptane-EtOAc (3:1)]