HRID1008120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：Cc1cc(C)c(/C=C2\C(=O)N(C(=O)OCC3O[C@@H]4OC(C)(C)O[C@@H]4[C@H]4OC(C)(C)O[C@@H]34)c3ccccc32)[nH]1$

HCID131724599

未命名化合物

PRODUCTS

生成物

$结构：Cc1cc(C)c(/C=C2\C(=O)N(C(=O)OCC3OC(O)[C@H](O)[C@@H](O)[C@H]3O)c3ccccc32)[nH]1$

HCID60111234

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid (3aR, 5aS, 8aS, 8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4′,5′-d]pyran-5-ylmethyl ester was dissolved in the mixture of 5.0 mL of 6 N HCl aq. and 20 mL of THF. The resultant mixture was stirred at room temperature for 3 h and 40° C. for 1 h and concentrated. The residue was washed with ethyl acetate and THF and dried to give 133 mg (60%) of 3-[1-(3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-indole-1-carboxylic acid (3R, 4S, 5R)-3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethyl ester as a yellow solid.

WORKUP

后处理

concentrationconcentrated
washThe residue was washed with ethyl acetate and THF
customdried