反应详情

(2R,3S)-2-(2,4-Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane (2.21 g, 8.8 mmol) and 1′,2′,3′,6′-tetrahydro-2,4′-bipyridine (7.47 g, 46.6 mmol) were dissolved in acetonitrile (100 ml), and lithium perchlorate trihydrate (7.48 g, 46.6 mmol) was added thereto and refluxed for 48 hours. The solvent was evaporated under a reduced pressure, and the thus obtained residue was dissolved in ethyl acetate and washed with water. The solvent was again evaporated under a reduced pressure, and the residue was purified using a silica gel column to obtain 1.90 g of the intended substance (yield 49.6%).

1. temperaturerefluxed for 48 hours
2. customThe solvent was evaporated under a reduced pressure
3. dissolutionthe thus obtained residue was dissolved in ethyl acetate
4. washwashed with water
5. customThe solvent was again evaporated under a reduced pressure
6. customthe residue was purified
7. customto obtain 1.90 g of the intended substance (yield 49.6%)