反应详情

(2R,3S)-2-(2,4Difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)oxirane (0.76 g, 3.0 mmol) and 5-methyl-1′,2′,3′,6′-tetrahydro-2,4′-bipyridine (1.63 g, 9.3 mmol) were dissolved in acetonitrile (20 ml), and lithium perchlorate trihydrate (1.50 g, 9.3 mmol) was added thereto and refluxed for 40 hours. The solvent was evaporated under a reduced pressure, and the thus obtained residue was dissolved in ethyl acetate and washed with water. The solvent was again evaporated under a reduced pressure, and the residue was purified using a silica gel column to obtain 0.63 g of the intended substance (yield 47.8%).

1. temperaturerefluxed for 40 hours
2. customThe solvent was evaporated under a reduced pressure
3. dissolutionthe thus obtained residue was dissolved in ethyl acetate
4. washwashed with water
5. customThe solvent was again evaporated under a reduced pressure
6. customthe residue was purified
7. customto obtain 0.63 g of the intended substance (yield 47.8%)