反应详情

To a methanol solution (1.2 mL) of (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-[2-(benzyloxy)-5-[4-[(1E)-4-[(2-hydroxy-1,1-dimethylethyl)amino]-4-oxobut-1-en-1-yl]benzyl]-4-methylphenyl]-D-glucitol (120 mg, 0.124 mmol) was added 10% palladium-activated carbon (22 mg), and the mixture was stirred overnight under a hydrogen atmosphere at room temperature. The reaction solution was filtered through celite, and evaporated under reduced pressure to obtain a residue. Thus obtained residue was purified with silica gel column chromatography (chloroform:methanol=20:1 to 5:1) to obtain the title compound (58 mg, 90%) as a colorless powder. NMR data and MS data of the compound are shown in Table 1.

1. filtrationThe reaction solution was filtered through celite
2. customevaporated under reduced pressure
3. customto obtain a residue
4. customThus obtained residue was purified with silica gel column chromatography (chloroform:methanol=20:1 to 5:1)