反应详情

A solution of 5-{4-[(phenylmethyl)oxy]-1-buten-1-yl}-3,6-dihydro-2H-pyran (2.03 g) and 10% palladium on carbon (88 mg) in ethyl acetate (83 ml) was hydrogenated at atmospheric pressure and room temperature. Hydrogen uptake (˜500 ml) was complete after 15 hours. The catalyst was filtered through celite and the filtrate concentrated in vacuo to afford a colourless oil. Analysis by 1H-NMR showed that the benzyl group was present in the majority of the compound. Hydrogenation was continued under the same conditions for a further 24 hours with additional hydrogen uptake of ˜300 ml. The catalyst was filtered through celite and the filtrate concentrated in vacuo to afford the title compound as a colourless oil (1.21 g).

1. customwas hydrogenated at atmospheric pressure and room temperature
2. filtrationThe catalyst was filtered through celite
3. concentrationthe filtrate concentrated in vacuo
4. customto afford a colourless oil
5. filtrationThe catalyst was filtered through celite
6. concentrationthe filtrate concentrated in vacuo