反应详情

To a round bottom flask equipped with a magnetic stir bar was added 4-(2-fluoro-4-nitro-phenoxy)-7H-pyrrolo[2,3-d]pyrimidine (0.5 g, 2.0 mmol, 1.0 eq.), 5% PtS (20% by weight, 120 mg) ammonium formate (451 mg, 6 eq), and ethanol (20 ml). The reaction mixture was heated at reflux with stirring for 30 min upon which the reaction was filtered hot through celite. Removal of the ethanol was followed by the addition of 1N HCl, which was further washed twice with DCM (50 ml). The aqueous layer was basified and extracted with DCM. The organic layer was then washed twice with brine (50 ml) and dried over sodium sulfate. After removal of solvent in vacuo, 3-fluoro-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-phenylamine as a brownish solid was obtained (0.281 g, 63%). MS (ESI) for C12H9FN4O: 244 (MH+).

1. customTo a round bottom flask equipped with a magnetic stir bar
2. temperatureThe reaction mixture was heated
3. temperatureat reflux
4. filtrationwas filtered hot through celite
5. customRemoval of the ethanol
6. additionwas followed by the addition of 1N HCl, which
7. washwas further washed twice with DCM (50 ml)
8. extractionextracted with DCM
9. washThe organic layer was then washed twice with brine (50 ml)
10. dry with materialdried over sodium sulfate
11. customAfter removal of solvent in vacuo