反应详情

0.5 g (1.07 mmol) 2-{[4-chloro-2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-1,3-thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione were dissolved in 20 ml THF. Then 0.2 g (2.14 mmol) piperidine were added dropwise and the mixture was stirred under reflux for 6 hours. After cooling to room temperature, stirring was continued overnight. The formed piperidine hydrochloric salt was separated by filtration and the solvent removed with a rotary evaporator. The resulting precipitate containing the crude product was recrystallized with toluene to obtain a dark powder.

1. temperatureunder reflux for 6 hours
2. stirringstirring
3. customThe formed piperidine hydrochloric salt was separated by filtration
4. customthe solvent removed with a rotary evaporator
5. additionThe resulting precipitate containing the crude product
6. customwas recrystallized with toluene
7. customto obtain a dark powder