反应详情

温度

80 °C

150 mg (0.43 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzofuran-2-carboxamide hydrochloride (Example 30A) and 71.3 mg (0.43 mmol) of 4-carboxyphenylboronic acid are introduced into 1.5 ml of DMF. Addition of 0.64 ml of 2 M sodium carbonate solution and 17.5 mg (0.02 mmol) of PdCl2(dppf) is followed by heating at 80° C. for 18 h. After cooling, the reaction mixture is filtered through kieselguhr, and the filtrate is concentrated and partitioned between water and ethyl acetate. The aqueous phase is washed with ethyl acetate and then concentrated. The crude product is purified by preparative HPLC. The product fractions are combined and concentrated and, after addition of a 3:1 mixture of acetonitrile and 1N hydrochloric acid, again concentrated. The crude product is stirred with acetonitrile. The precipitate is filtered off with suction and dried under high vacuum to result in 37 mg (20% of theory) of the title compound.

1. temperatureAfter cooling
2. filtrationthe reaction mixture is filtered through kieselguhr
3. concentrationthe filtrate is concentrated
4. custompartitioned between water and ethyl acetate
5. washThe aqueous phase is washed with ethyl acetate
6. concentrationconcentrated
7. customThe crude product is purified by preparative HPLC
8. concentrationconcentrated
9. additionafter addition of a 3:1 mixture of acetonitrile and 1N hydrochloric acid
10. concentrationagain concentrated
11. filtrationThe precipitate is filtered off with suction
12. customdried under high vacuum