反应详情

温度

85 °C

110 mg (0.73 mmol) of 4-(hydroxymethyl)phenylboronic acid and 1.46 ml of 1N sodium hydroxide solution are added to a mixture of 170 mg (0.49 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-5-bromo-1-benzofuran-2-carboxamide (Example 3A) and 35 mg (0.05 mmol) of PdCl2(dppf) in 2 ml of DMF. The reaction mixture is heated at 85° C. overnight. The solvent is removed under reduced pressure. Addition of a mixture of 1N sodium hydroxide solution and ethyl acetate to the residue is followed by extraction of the aqueous phase once more with ethyl acetate. The combined organic phases are washed twice with each of 1N sodium hydroxide solution and saturated sodium chloride solution, dried over magnesium sulphate and concentrated in a rotary evaporator under reduced pressure. The crude product is taken up in methanol and shaken together with acidic ion exchanger (Dowex® WX2-200) for about 20 min. The loaded ion exchanger is washed three times with 30 ml of methanol each time, then with DMF, again with methanol, with dichloromethane, again with methanol, with water and finally with methanol again. The product is eluted with methanol/triethylamine 95:5. The solvent is removed in a rotary evaporator under reduced pressure. 148 mg (80% of theory) of the title compound are isolated.

1. customThe solvent is removed under reduced pressure
2. additionAddition of a mixture of 1N sodium hydroxide solution and ethyl acetate to the residue
3. extractionis followed by extraction of the aqueous phase once more with ethyl acetate
4. washThe combined organic phases are washed twice with each of 1N sodium hydroxide solution and saturated sodium chloride solution
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated in a rotary evaporator under reduced pressure
7. washThe loaded ion exchanger is washed three times with 30 ml of methanol each time
8. washThe product is eluted with methanol/triethylamine 95:5
9. customThe solvent is removed in a rotary evaporator under reduced pressure