反应详情

Using General Protocol II (but using methanol in place of dimethylether) and starting with 2,4-dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 13.2 mmol) and 3-amino-2-naphthalenecarboxamide (3.00 g, 8.8 mmol), 3-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-2-naphthalenecarboxamide was isolated as a white solid (2.56 g, 59% Yield); 1H NMR (400 MHz, DMSO-d6) δ ppm 2.35 (s, 3 H), 6.69 (d, J=4.03 Hz, 1 H), 7.42-7.51 (m, 3 H), 7.58 (t, J=7.51 Hz, 1 H), 7.72 (d, J=4.03 Hz, 1 H), 7.78-7.85 (m, 2 H), 7.90 (d, J=8.06 Hz, 1 H), 7.97 (d, J=8.42 Hz, 2 H), 8.40 (s, 2 H), 8.69 (s, 1 H), 11.90 (s, 1 H).