反应详情

A mixture of benzyl[2-[4-(2-Oxopyrrolidin-1-yl)phenyl)hexahydro-2,5-methanopentalene-3a(1H)-yl]carbamate (0.73 g, 1.7 mmol) obtained in step I and Pd/C (10%, 0.4 g) in MeOH (17 mL) was stirred at room temperature under H2 atmosphere for 2 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated under reduced pressure to obtain 1-[4-(3-aminotricyclo[3.3.1.03,7]non-1-yl)phenyl]pyrrolidin-2-one as an off-white solid (0.43 g, 85% yield). m/z (M+1) 297; 1H NMR (CDCl3) 300 MHz δ 7.52 (d, J=8.6 Hz, 2H), 7.25 (d, J=8.6 Hz, 2H), 3.86 (t, J=6.9 Hz, 2H), 2.62 (t, J=7.9 Hz, 2H), 2.52-2.42 (m, 1H), 2.32-1.60 (m, 13H).

1. filtrationThe reaction mixture was filtered through a pad of celite
2. concentrationthe filtrate was concentrated under reduced pressure