2-Methoxyethylamine → HCID 24772473, compound

HRID 1015591Notes

Reaction equation

[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:15])([CH3:14])[C:9]=2[C:8]=1[C:19](O)=[O:20])=[O:5].[CH3:30][O:31][CH2:32][CH2:33][NH2:34]>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:18][C:10]2[C:11]([CH3:17])([CH3:16])[O:12][C:13]([CH3:14])([CH3:15])[C:9]=2[C:8]=1[C:19]([NH:34][CH2:33][CH2:32][O:31][CH3:30])=[O:20])=[O:5]

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 67300640HCID 67300640, compound

Product 1

HCID 24772473HCID 24772473, compound

Procedure

The title compound was prepared from the product of Example 45A and 2-methoxyethylamine using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.45 (s, 6H), 1.48 (s, 6H), 3.18 (s, 3H), 3.31-3.41 (m, 4H), 7.68-7.82 (m, 3H), 7.99 (t, J=5.3 Hz, 1H), 11.51 (br s, 1H). MS (ESI+) m/z 489 (M+H)+. Anal. calcd. for C22H24F4N2O4S: C, 54.09; H, 4.95; N, 5.73. Found: C, 53.88; H, 4.65; N, 5.71.

Sources & evidence

ORD record: ord-ab68e50e764b4c5a9cf7ce5d76273251
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07985768B2

Reaction notes

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