反应详情

A mixture of (1R*,2S*,5S*,6RS)-8-benzyl-2-(3-hydroxypropynyl)-1-phenyl-6-(tert-butoxycarbonyl)-8-azabicylco[3.2.1]octan-2-ol (Description 25; a 3:1 mixture of C6 epimers, 4 g, 8.9 mmol), Lindlar catalyst (800 mg) and ethyl acetate (30 ml) was stirred under hydrogen atmosphere (1 atm) at room temperature for 45 minutes. The reaction mixture was filtered through a pad of Celite™. The filtrate was concentrated to give the title compound (4.0 g, 100%) as a 3:1 mixture of C6 epimers.

1. filtrationThe reaction mixture was filtered through a pad of Celite™
2. concentrationThe filtrate was concentrated