反应详情

A suspension of 0.34 g (1.58 mmol) of 2-(3,3-difluoroazetidin-1-yl)-5-nitropyridine, prepared in the preceding stage, and 8 mg of Pd/C at 10% in 10 mL of ethanol is stirred vigorously at 20° C. under 5 atm of hydrogen for 4 hours. After this time, the mixture is filtered on a Celite pad, then concentrated at reduced pressure. The resultant product is purified by chromatography on a silica column, eluting with a mixture of dichloromethane and methanol. We thus obtain 0.188 g of the expected product in the form of a red powder, which is used as it is in the rest of the synthesis.

1. filtrationAfter this time, the mixture is filtered on a Celite pad
2. concentrationconcentrated at reduced pressure
3. customThe resultant product is purified by chromatography on a silica column
4. washeluting with a mixture of dichloromethane and methanol
5. customis in the rest of the synthesis