HRID1020533

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID268029

4-phenethyl-1H-pyridin-2-one

C13H13NO

结构：Cn1c2c(c3ccc(Br)cc31)CN(C(=O)OC(C)(C)C)CC2

HCID57950375

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

C17H21BrN2O2

PRODUCTS

生成物

结构：Cn1c2c(c3ccc(-n4ccc(CCc5ccccc5)cc4=O)cc31)CN(C(=O)OC(C)(C)C)CC2

HCID57950300

未命名化合物

收率 48%

PROCEDURE

实验过程

The compound was prepared from tert-butyl 7-bromo-5-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (200 mg, 0.548 mmol) and 4-phenethylpyridin-2(1H)-one (109 mg, 0.548 mmol) according to the procedure in Example 1 (step c). Purification by flash column chromatography (silica gel, hexanes/EtOAc, 100:0 to 80:20 to 50:50 to 25:75 then 0:100) provided the title compound (126 mg, 48%) as a yellow solid:

WORKUP

后处理

customPurification by flash column chromatography (silica gel, hexanes/EtOAc, 100:0 to 80:20 to 50:50 to 25:75