反应详情

(3-Bromophenyl)methanol (5.0 g) was mixed with THF (60 ml), and TBSCl (5.0 g) and imidazole (3 g) were added thereto, followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and water and EtOAc were added thereto. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain [(3-bromobenzyl)oxy](tert-butyl)dimethylsilane (8.0 g).

1. additionwere added
2. concentrationThe reaction mixture was concentrated under reduced pressure, and water and EtOAc
3. additionwere added
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure
6. customThe obtained residue was purified by silica gel column chromatography