Hydrochloric Acid → 4-(Diphenylamino)cinnamic acid

Temperature

140 °C

All glassware was dried in a drying oven heated to 140° C. Malonic acid was dried on a high vacuum line over P2O5 and then stored in a nitrogen purged glovebox. Pyridine (Aldrich, anhydrous, 99.8%) and piperidine were used as received and stored in the glovebox. In a 100 mL round bottom flask equipped with a stir bar, condenser and nitrogen inlet-outlet was dissolved malonic acid (2.3 g, 22.0 mmol) in 20 mL pyridine. 4-(N,N-Diphenylamino)benzaldehyde (5.0 g, 18.3 mmol) was added and addition of 20 mL pyridine was necessary to obtain a solution. Piperidine (0.18 mL, 1.8 mmol) was added and the solution was heated to reflux. After heating for 25 hours, malonic acid (0.60 g, 5.8 mmol) was added and heating was resumed for an additional 2.5 h after which time no further reaction was observed. The reaction mixture was allowed to cool to room temperature and then poured into a stirring mixture of 12 N HCl in ice water (1:5). The mixture was filtered and the solids rinsed three times with 20 mL water. The solids were collected and the crude product was purified by recrystallization from 5:3 hexanes:EtOAc at 4° C. The mother liquor was concentrated and recrystallized in a similar fashion from 7:3 hexanes:ethyl acetate. The combined crops give 3.1 g of a light brown powder. The yield was 55%.

1. customAll glassware was dried in a drying oven
2. dry with materialMalonic acid was dried on a high vacuum line over P2O5
3. customstored in a nitrogen purged glovebox
4. customIn a 100 mL round bottom flask equipped with a stir bar, condenser and nitrogen inlet-outlet
5. customto obtain a solution
6. temperaturethe solution was heated to reflux
7. temperatureAfter heating for 25 hours
8. temperatureheating
9. customafter which time no further reaction
10. temperatureto cool to room temperature
11. filtrationThe mixture was filtered
12. washthe solids rinsed three times with 20 mL water
13. customThe solids were collected
14. customthe crude product was purified by recrystallization from 5:3 hexanes
15. customat 4° C
16. concentrationThe mother liquor was concentrated
17. customrecrystallized in a similar fashion from 7:3 hexanes

ORD record

ord-e521967cd32448b7b3c6311cd4ca2f6a

Source dataset

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08716697B2