反应详情

A portion of 2-(2-bromo-4-chlorophenyl)acetonitrile (7.1 g; 39.1 mmol) was directly dissolved in borane solution (78.2 mL of a 1.0 M solution in tetrahydrofuran; 78.2 mmol), and the resulting solution was stirred and heated to reflux. After refluxing for a total of 90 minutes, the heat was removed and the solution was allowed to cool for a few minutes, and then 16 mL of methanol was carefully added to quench the solution. The resulting solution was again heated to reflux for 30 minutes. The solvent was then evaporated, and the residue was partitioned between 200 mL of 1M HCl (aq.) and 200 mL ether. The aqueous layer was filtered to remove a small amount of suspended insoluble material, and the pH of the filtrate was adjusted to pH>12 by the addition of 42% NaOH (aq.). The filtrate was then extracted with 200 mL dichloromethane. The organic layer was dried over sodium sulfate and evaporated to give 3.89 g of 2-(4-chloro-2-methoxyphenyl)ethanamine as a colorless liquid. MS (apci, pos) m/z=186.

1. temperatureheated to reflux
2. temperatureAfter refluxing for a total of 90 minutes
3. customthe heat was removed
4. temperatureto cool for a few minutes
5. addition16 mL of methanol was carefully added
6. customto quench the solution
7. temperatureThe resulting solution was again heated
8. temperatureto reflux for 30 minutes
9. customThe solvent was then evaporated
10. customthe residue was partitioned between 200 mL of 1M HCl (aq.) and 200 mL ether
11. filtrationThe aqueous layer was filtered
12. customto remove a small amount of suspended insoluble material
13. additionthe pH of the filtrate was adjusted to pH>12 by the addition of 42% NaOH (aq.)
14. extractionThe filtrate was then extracted with 200 mL dichloromethane
15. dry with materialThe organic layer was dried over sodium sulfate
16. customevaporated