反应详情

0.55 g of 6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-thiopyran-4-yl)-quinazoline-2,4(1H,3H)-dione and 0.196 g of Oxone® in 100 ml of an MeOH/water mixture (10/1) (v/v) is stirred at room temperature overnight. The resulting mixture is evaporated under reduced pressure. Water is added and the resulting mixture is extracted with DCM. The organic phase is dried over Na2SO4. The resulting solution is filtered and the filtrate is then evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a heptane/EtOAc mixture from (50/50, v/v) to (0/100, v/v) to give 0.454 g of the expected product.

1. customThe resulting mixture is evaporated under reduced pressure
2. additionWater is added
3. extractionthe resulting mixture is extracted with DCM
4. dry with materialThe organic phase is dried over Na2SO4
5. filtrationThe resulting solution is filtered
6. customthe filtrate is then evaporated under reduced pressure
7. customThe residue is chromatographed on silica gel
8. washeluting with a heptane/EtOAc mixture from (50/50