反应详情

To a solution of 2-(benzyloxy)-4-ethylphenyl-4-methylbenzenesulfonate methylbenzenesulfonate (0.26 mmol; 100 mg) under argon, in methanol (2 mL), was added magnesium (2.61 mmol; 0.63 g). The reaction was stirred at room temperature overnight. The reaction mixture was hydrolysed with HCl 1N (3 mL) and extracted with ethyl acetate (3*5 mL). Combined organic phases were washed with saturated NaHCO3 (10 mL), dried over Na2SO4, concentrated. The residue was purified with preparative TLC (dichloromethane/cyclohexane: 9/1) to yield the title compound as a yellow oil (48 mg; 0.21 mmol; 80%).

1. extractionextracted with ethyl acetate (3*5 mL)
2. washCombined organic phases were washed with saturated NaHCO3 (10 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe residue was purified with preparative TLC (dichloromethane/cyclohexane: 9/1)