反应详情

To a solution of N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R)-1-methyl-2-(triphenylmethoxy)ethoxy]-4-pyrimidinyl]-4-pyridinesulfonamide (the product from step iv). (100 mg) in MeOH (10 mL) was added p-toluenesulfonic acid (31 mg) and anisole (0.15 g). The reaction was then stirred at room temperature for 18 h. The reaction was partitioned between EtOAc (100 mL) and H2O (100 mL). The aqueous layer was then further extracted with EtOAc (2×100 mL). The combined organic layers were dried (MgSO4), filtered and evaporated. The residue was purified by reverse phase HPLC using a TFA (0.2%)/MeCN to give the title compound as a white solid. Yield: 50 mg.

1. customThe reaction was partitioned between EtOAc (100 mL) and H2O (100 mL)
2. extractionThe aqueous layer was then further extracted with EtOAc (2×100 mL)
3. dry with materialThe combined organic layers were dried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by reverse phase HPLC