反应详情

A solution of tert-butyl (2-{4-[({2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}amino)sulfonyl]piperazin-1-yl}-2-oxoethyl)carbamate (the product of step u, 0.19 g) in 10% TFA/DCM (5 mL) was stirred at room temperature for 3 h. The solution was evaporated, and then redissolved in 4N in dioxane (2 mL) and MeOH (8 mL). Evaporation gave a crude residue that was triturated in Et2O, filtered and dried in a vacuum oven at 40° C. overnight to give the title compound as a white solid. Yield: 140 mg.

1. customThe solution was evaporated
2. dissolutionredissolved in 4N in dioxane (2 mL)
3. customEvaporation
4. customgave a crude residue that
5. customwas triturated in Et2O
6. filtrationfiltered
7. customdried in a vacuum oven at 40° C. overnight