反应详情

To an acetonitrile solution (400 ml) of 2,5-dichloropyridin-3-ol (20.0 g) (Synthesis, 1990, 6, 499-501) and tert-butyl 2-bromo-2-methylpropionate (54.4 g) was added at room temperature potassium carbonate (30.3 g), followed by stirring for 12 hours under heating at reflux. The insolubles were filtered off, and washed with ethyl acetate. The filtrate was concentrated under reduced pressure, and then the residue was purified by silica gel chromatography to afford tert-butyl 2-[(2,5-dichloropyridin-3-yl)oxy]-2-methylpropionate (31.1 g).

1. temperatureunder heating
2. temperatureat reflux
3. filtrationThe insolubles were filtered off
4. washwashed with ethyl acetate
5. concentrationThe filtrate was concentrated under reduced pressure
6. customthe residue was purified by silica gel chromatography