反应详情

To 3-bromo-7-hydroxy-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine (7.7 g, 19.1 mmol) obtained in step 2 were added phosphorus oxychloride (100 mL) and N,N-diethylaniline (6.1 mL, 38.3 mmol), and the mixture was heated under reflux for 5 hr. The reaction mixture was concentrated under reduced pressure, the residue was diluted with ethyl acetate (100 mL) and neutralized with saturated aqueous sodium hydrogen carbonate solution (300 mL) under ice-cooling, and the organic layer and the aqueous layer were separated. The organic layer was washed with 10% aqueous citric acid solution (50 mL) and saturated brine (100 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to give the title compound (7.5 g, 93%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hr
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additionthe residue was diluted with ethyl acetate (100 mL)
5. temperaturecooling
6. customthe organic layer and the aqueous layer were separated
7. washThe organic layer was washed with 10% aqueous citric acid solution (50 mL) and saturated brine (100 mL)
8. dry with materialdried over anhydrous magnesium sulfate
9. concentrationconcentrated under reduced pressure
10. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1)