HCID 178442670, compound → 3-(4-Oct-1-enyl-1H-pyrazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine

HRID 1027546Notes

Reaction equation

HRID 1027546 reaction equation
[CH:1]([C:9]1[C:10]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[N:11][NH:12][CH:13]=1)=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH3:20]SC1C(C2C=NC=CC=2)=NNC=1>>[CH:1]([C:9]1[C:10]([C:14]2[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][CH:19]=2)=[N:11][NH:12][CH:13]=1)=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 178442670HCID 178442670, compoundHCID 178503312HCID 178503312, compound

Product 1

HCID 1784426713-(4-Oct-1-enyl-1H-pyrazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine

Procedure

3-(4-Oct-1-enyl-1H-pyrazol-3-yl)-pyridine was converted to the title compound 47C, using the methodology described for the conversion of 21A to 22A (see Scheme 3). Yield: 95% (amorphous). 1H-NMR (400 MHz, CDCl3): δ 7.58 (s, 1H), 6.24 (bd, J=16 Hz, 1H), 6.07-6.02 (m, 1H), 5.98-5.89 (m, 1H), 3.29-3.25 (m, 2H), 2.63 (bt, J=7 Hz, 2H), 2.46 (s, 3H), 2.44-2.38 (m, 2H), 2.18-2.12 (m, 2H), 1.46-1.38 (m, 2H), 1.38-1.24 (m, 6H), 0.91 (t, J=7 Hz, 3H).

Sources & evidence

ORD record
ord-0840ab20408647f8937484d5470dded9
Source dataset
uspto-grants-2014_05
Patent number
US08735388B2

Reaction notes

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