反应详情

The title compound was prepared using the procedure outlined in Example 59D substituting piperazine for t-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate, and substituting the product from Example 118C for the product from Example 59C. The product was purified by chromatography on silica gel eluting with NH4OH:MeOH:CHCl3 (0.8:8:92) to provide the title compound. 1H NMR (CD3OD) δ 2.32-2.49 (m, 4H), 2.63-2.70 (m, 2H), 2.94-3.01 (m, 4H), 3.47-3.54 (m, 4H), 7.30-7.35 (m, 1H), 7.39-7.44 (m, 2H), 7.65-7.71 (m, 1H), 8.58-8.61 (m, 1H). MS (M+H)+ m/z 281.

1. customThe title compound was prepared
2. customThe product was purified by chromatography on silica gel eluting with NH4OH:MeOH:CHCl3 (0.8:8:92)