反应详情

In tetrahydrofuran were dissolved and suspended 66.5 g of 2',4',6'-trihydroxyacetophenone and 173.0 g of potassium carbonate, and 56.0 ml of 1-chloro-3-methyl-2-butene was dropped into the solution. The mixture was stirred at room temperature for 2 hours and extracted with dimethyl ether, and the organic layer was washed with a 5% solution of potassium carbonate and then with water. The organic layer was shaken with a saturated solution of sodium chloride, dried with anhydrous sodium sulfate and concentrated under a reduced pressure. Recrystallization from benzene gave 31.8 g (yield=34.0%) of 2',4',6'-trihydroxy-3'-(3-methyl-2-butenyl)acetophenone.

1. additionwas dropped into the solution
2. extractionextracted with dimethyl ether
3. washthe organic layer was washed with a 5% solution of potassium carbonate
4. stirringThe organic layer was shaken with a saturated solution of sodium chloride
5. dry with materialdried with anhydrous sodium sulfate
6. concentrationconcentrated under a reduced pressure
7. customRecrystallization from benzene