反应详情

To 15 ml of an ether solution of 1.5 g (8.57 mmols) of 1,1-dimethylindane-4-amine,2 ml of N-methyl morpholine and 1.4 g (8.83 mmols) of 2,5-dimethyl-3-furan carboxylic acid chloride were added under cooling. The mixture was stirred at room temperature for 1 hour and then washed sequentially with water and brine. The solution was dried with magnesium sulfate. The resultant concentrate was purified with silica gel column chromatography (solvent for elution; ethyl acetate/ n-hexane =1/4), thereby obtaining 2.1 g of light yellow crystals (Compound No. 20 shown in Table 6). The yield was 85.8%.

1. temperatureunder cooling
2. washwashed sequentially with water and brine
3. dry with materialThe solution was dried with magnesium sulfate
4. concentrationThe resultant concentrate
5. customwas purified with silica gel column chromatography (solvent for elution; ethyl acetate/ n-hexane =1/4)