反应详情

305 mg of (2S,4S)-4-(4-methoxybenzylthio)-2-(4-methyl-1-piperazinylcarbonyl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine (prepared as described in Preparation 1) were suspended in 627 μl of anisole, and then the suspension was placed over an ice bath. 3.14 ml of trifluoroacetic acid and 56 μl of trifluoromethanesulfonic acid were then added to the suspension, and the resulting mixture was stirred for 1 hour at room temperature. At the end of this time, the solvent was removed by distillation under reduced pressure. The residue was washed with diethyl ether by repeated decantation, after which it was dried under reduced pressure to obtain 318 mg of the title compound.

1. customthe suspension was placed over an ice bath
2. customAt the end of this time, the solvent was removed by distillation under reduced pressure
3. washThe residue was washed with diethyl ether by repeated decantation
4. customafter which it was dried under reduced pressure