反应详情

Cyclopropanecarbonyl chloride (63.1 μL, 0.676 mmol) was added dropwise to 5-ethoxy-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine (120 mg, 0.615 mmol) in pyridine (5 mL) at 0° C. The reaction was stirred at about 0 to about 5° C. for 2 hours and then concentrated to dryness. Water (10 mL) was added and extracted with CHCl3/IPA (3:1). The combined organic phases were dried over MgSO4 and concentrated to yield N-(5-ethoxy-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (90 mg, 55% yield) as a solid.

1. concentrationconcentrated to dryness
2. additionWater (10 mL) was added
3. extractionextracted with CHCl3/IPA (3:1)
4. dry with materialThe combined organic phases were dried over MgSO4
5. concentrationconcentrated