反应详情

Using a similar protocol as described in Example 16 employing 19B (0.20 g, 0.80 mmol) and ethyl 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-carboxylate (0.22 g, 0.88 mmol) as starting materials afforded 0.21 g (46%) of 19 as a solid. 1H NMR (500 MHz, CDCl3): δ 1.72-1.84 (m, 4H), 2.35 (s, 3H), 2.43-2.58 (m, 4H), 3.54 (s, 2H), 4.28-4.36 (m, 1H), 4.59-4.68 (m, 1H), 4.70-4.78 (m, 1H), 5.02-5.16 (m, 2H), 6.55 (d, 1H), 6.60 (s, 1H), 7.23 (d, 1H), 7.52 (d, 2H), 8.11 (d, 2H), MS (APCI+) m/z 453 [M+H]+, LC purity: 94%.