HRID1036480

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：Cc1c(O[C@H]2CC[C@H](C(C)(C)C)CC2)ccc2cc([C@]3(C)COC(=O)N3)ccc12

HCID178431625

未命名化合物

反应SMILES：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2C2CC2)CC1

HCID178445747

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1c(O[C@H]2CC[C@H](C(C)(C)C)CC2)ccc2cc([C@@](C)(N)CO)ccc12

HCID178431626

未命名化合物

收率 64%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-methylnaphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-cyclopropylnaphthalen-2-yl)propan-1-ol (Example 215) in 64% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-methylnaphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z=353.44 [M−16]+. 1H NMR (MeOD) δ: 8.06 (d, J=9.0 Hz, 1H), 7.86 (d, J=2.0 Hz, 1H), 7.77 (d, J=9.0 Hz, 1H), 7.58 (dd, J=9.0, 2.3 Hz, 1H), 7.40 (d, J=9.0 Hz, 1H), 4.21-4.31 (m, 1H), 3.95 (d, J=11.5 Hz, 1H), 3.84 (d, J=11.5 Hz, 1H), 2.53 (s, 3H), 2.17-2.26 (m, 2H), 1.87-1.95 (m, 2H), 1.80 (s, 3H), 1.42-1.56 (m, 2H), 1.10-1.28 (m, 3H), 0.93 (s, 9H)