huagongshe.com
HRID1036486

反应详情

EQUATION

反应方程式

HRID 1036486 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@]4(C)COC(=O)N4)ccc3c2-c2ccc(S(C)(=O)=O)cc2)CC1
HCID178445728

未命名化合物

结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(OC(F)(F)F)cc2)CC1
HCID178445751

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(S(C)(=O)=O)cc2)CC1
HCID178445752

未命名化合物

收率 36%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(methylsulfonyl)phenyl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 36% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(methylsulfonyl)phenyl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z 493.26 [M−16]+. 1H NMR (MeOD) δ: 8.03-8.12 (m, 2H), 7.91-7.99 (m, 2H), 7.55-7.63 (m, 2H), 7.42-7.53 (m, 2H), 7.32-7.40 (m, 1H), 4.21 (br. s., 1H), 3.58-3.76 (m, 2H), 3.25 (br. s., 3H), 2.05 (br. s., 2H), 1.80 (br. s., 2H), 1.52 (br. s., 3H), 1.05-1.25 (m, 4H), 0.90-1.04 (m, 1H), 0.87 (br. s., 9H)