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HRID1036490

反应详情

EQUATION

反应方程式

HRID 1036490 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(OC(F)(F)F)cc2)CC1
HCID178445751

未命名化合物

结构：CCOc1ccc(-c2c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc3cc([C@]4(C)COC(=O)N4)ccc23)cc1
HCID178466108

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1ccc(-c2c(O[C@H]3CC[C@H](C(C)(C)C)CC3)ccc3cc([C@@](C)(N)CO)ccc23)cc1
HCID178466109

未命名化合物

收率 35%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-ethoxyphenyl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 35% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-ethoxyphenyl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS; m/z=459.45 [M−16]+. 1H NMR (MeOD) δ: 7.91-7.95 (m, 1H), 7.83-7.88 (m, 1H), 7.53 (d, J=9.0 Hz, 1H), 7.44-7.49 (m, 1H), 7.37 (s, 1H), 7.19-7.26 (m, 2H), 7.01-7.07 (m, 2H), 4.10-4.19 (m, 2H), 3.98-4.07 (m, 1H), 3.73 (d, J=10.8 Hz, 1H), 3.69 (d, J=11.0 Hz, 1H), 1.97-2.04 (m, 2H), 1.75-1.82 (m, 2H), 1.52 (s, 3H), 1.48 (t, J=6.9 Hz, 3H), 1.14-1.23 (m, 2H), 0.96-1.12 (m, 3H), 0.87 (s, 9H)