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HRID1036492

反应详情

EQUATION

反应方程式

HRID 1036492 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@]4(C)COC(=O)N4)ccc3c2-c2ccccc2)CC1
HCID178445724

未命名化合物

结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(OC(F)(F)F)cc2)CC1
HCID178445751

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccccc2)CC1
HCID178445748

未命名化合物

收率 88%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-phenylnaphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 88% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-phenylnaphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z=415.44 [M−NH2]+. 1H NMR (MeOD) δ: 7.93 (s, 1H), 7.88 (d, J=9.0 Hz, 1H), 7.44-7.52 (m, 4H), 7.38-7.44 (m, 2H), 7.29-7.34 (m, 2H), 4.00-4.09 (m, 1H), 3.66-3.75 (m, 2H), 1.97-2.04 (m, 2H), 1.75-1.82 (m, 2H), 1.52 (s, 3H), 0.92-1.23 (m, 5H), 0.86 (s, 9H)