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HRID1036494

反应详情

EQUATION

反应方程式

HRID 1036494 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@]4(C)COC(=O)N4)ccc3c2-c2cccc(Cl)c2)CC1
HCID178445725

未命名化合物

结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(OC(F)(F)F)cc2)CC1
HCID178445751

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2cccc(Cl)c2)CC1
HCID178445749

未命名化合物

收率 82%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(3-chlorophenyl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 82% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(3-chlorophenyl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z=449.40 [M−16]+. 1H NMR (MeOD) δ: 7.93 (d, J=2.0 Hz, 1H), 7.90 (d, J=9.0 Hz, 1H), 7.47-7.52 (m, 1H), 7.45 (d, J=7.3 Hz, 1H), 7.38-7.44 (m, 3H), 7.30 (d, J=1.5 Hz, 1H), 7.23 (dd, J=7.2, 1.4 Hz, 1H), 4.08-4.17 (m, 1H), 3.72 (d, J=10.8 Hz, 1H), 3.67 (d, J=10.8 Hz, 1H), 1.98-2.09 (m, 1.75-1.84 (m, 2H), 1.51 (s, 3H), 1.03-1.23 (m, 4H), 0.90-1.02 (m, 1H), 0.85 (s, 9H)