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HRID1036496

反应详情

EQUATION

反应方程式

HRID 1036496 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@]4(C)COC(=O)N4)ccc3c2-c2ccc(Cl)cc2)CC1
HCID178445726

未命名化合物

结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(OC(F)(F)F)cc2)CC1
HCID178445751

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[C@H]1CC[C@H](Oc2ccc3cc([C@@](C)(N)CO)ccc3c2-c2ccc(Cl)cc2)CC1
HCID178445750

未命名化合物

收率 81%

PROCEDURE

实验过程

(R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-chlorophenyl)naphthalen-2-yl)propan-1-ol was synthesized as per (R)-2-amino-2-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-(trifluoromethoxy)phenyl)naphthalen-2-yl)propan-1-ol (Example 221) in 81% yield using (R)-4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(4-chlorophenyl)naphthalen-2-yl)-4-methyloxazolidin-2-one as starting material. MS: m/z=449.41 [M−16]+. 1H NMR (MeOD) δ: 7.94 (d, J=1.8 Hz, 1H), 7.90 (d, J=8.8 Hz, 1H), 7.46-7.52 (m, 3H), 7.42 (d, J=9.3 Hz, 2H), 7.29 (d, J=8.0 Hz, 2H), 4.07-4.17 (m, 1H), 3.66-3.75 (m, 2H), 2.00-2.08 (m, 2H), 1.77-1.84 (m, 2H), 1.52 (s, 3H), 0.92-1.25 (m, 5H), 0.84-0.89 (m, 9H)