反应详情

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, (1-{-4-[4-oxo-2-phenyl-7-(2H-pyrazol-3-yl)-4H-chromen-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester was reacted to give the title compound as a cream solid (27 mg, 92%). 1H NMR (400 MHz, DMSO-d6): δ 13.36-13.12 (br s, 1H), 8.14-8.11 (m, 2H), 8.05-8.00 (m, 1H), 7.90-7.83 (br s, 1H), 7.48-7.33 (m, 7H), 7.21-7.17 (m, 2H), 7.00 (d, J=3 Hz, 1H), 2.47-2.39 (m, 2H), 2.24-2.15 (m, 2H), 2.08-1.97 (m, 1H), 1.73-1.64 (m, 1H). LCMS (Method F): RT=8.99 min, [M+H]+=434.

1. customwas reacted