反应详情

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-carbamoyl-6-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a pale yellow solid (17 mg, 93%). 1H NMR (400 MHz, DMSO-d6): δ 7.99 (s, 1H), 7.91-7.88 (br s, 1H), 7.85-7.81 (br s, 1H), 7.59 (s, 1H), 7.45-7.31 (m, 7H), 7.16-7.11 (m, 2H), 3.98 (s, 3H), 2.41-2.33 (m, 2H), 2.13-2.04 (m, 2H), 2.04-1.94 (m, 1H), 1.70-1.60 (m, 1H). LCMS (Method E): RT=2.99 min, [M+H]+=441.

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