反应详情

TFA: Following the procedure used to make 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-1-benzopyran-4-one, {1-[4-(7-amino-4-oxo-2-phenyl-4H-1-benzopyran-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (6.3 mg, 0.017 mmol) was reacted to give the title compound as a yellow solid (10.2 mg, 100%). 1H-NMR (400 MHz, D2O) δ 7.30 (d, 1H), 7.05-7.18 (m, 4H), 6.85 (dd, 2H), 6.59-6.65 (m, 4H) 5.65 (s, 1H) 2.33-2.47 (m, 4H), 1.95-2.02 (m, 1H), 1.52-1.59 (m, 1H). LCMS (Method I): RT=3.97 min, [M+H]+=384.

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