反应详情

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(7-amino-8-hydroxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a yellow solid (9 mg, 45%). 1H NMR (400 MHz, DMSO-d6): δ 7.48 (m, 2H), 7.39 (d, J=8.6 Hz, 1H), 7.37-7.27 (m, 5H), 7.09-7.05 (m, 2H), 6.78 (d, J=8.6 Hz, 1H), 5.76-5.69 (br s, 2H), 2.39-2.32 (m, 2H), 2.10-2.02 (m, 2H), 2.02-1.93 (m, 1H), 1.68-1.60 (m, 1H). LCMS (Method E): RT=2.81 min, [M+H]+=399.

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